The role N-acetylcysteine (nac) in the therapy of diseases characterized by oxidative stress (literature review)

Abstract

Oxidative stress is a ubiquitous cellular process that results in damage to various biological  molecules and it is involved in the etiopathogenesis of many diseases. The sulfhydryl-containing tripeptide glutathione (GSH), which is synthesized and maintained in high concentrations  in all cells, is a component of one of the defense mechanisms. N-acetylcysteine, a synthetic  derivative of the endogenous amino acid L-cysteine and a precursor of GSH, has been used for  several decades as a mucolytic and antidote for acetaminophen (paracetamol) poisoning. As a  mucolytic, N-acetylcysteine breaks the disulfide bonds of highly cross-linked mucins, thereby  reducing the viscosity of the mucus. As an antidote for acetaminophen poisoning, N-acetylcysteine restores the hepatic GSH pool depleted during drug detoxification. More recently,  enhance knowledge of N-acetylcysteine’s mechanisms of action has expanded its clinical use.  This publication presents an overview of the most relevant and recent data on the clinical use of  N-acetylcysteine in transplantology, neurology and ophthalmology.