Therapeutic Effect of Gypenoside on Chronic Liver Injury and Fibrosis Induced by CCl4 in Rats

Author:

Chen Jung-Chou12,Tsai Chin-Chuan3,Chen Leih-Der3,Chen Hing-Ho1,Wang Wen-Chuang4

Affiliation:

1. Research Institute of Chinese Medicine, Chinese Medical College, Taichung, Taiwan

2. Department of Chinese Medicine, Show Chwan Memorial Hospital, Changhua, Taiwan

3. School of Post-Baccalaureate, China Medical College, Taichung, Taiwan

4. Department of Pathology, Chiayi Christian Hospital, Taiwan

Abstract

Gypenoside is a saponins extract derived from the Gynostemma pentaphyllum. The purpose of this study was to evaluate the hepatoprotective and antifibrotic potential of Gypenoside on chronic liver injury induced by CCl 4 for 8 wks. The results indicated that the increase of SGOT, SGPT activities in CCl 4 liver injury were significantly reduced by treatment with Gypenoside. It also elevated the A/G ratio. For the study of anti-fibrotic potential, Gypenoside reduced the collagen content by 33%. These phenomena were confirmed by pathologic observation; thinner bands of liver collagen were found. The results suggest that Gypenoside has hepatoprotective and anti-fibrotic activities.

Publisher

World Scientific Pub Co Pte Lt

Subject

Complementary and alternative medicine,General Medicine

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