Antioxidant and Antiproliferative Activities of Crossostephium chinensis (L.) Makino

Author:

Chang Tien-Ning1,Huang Guan-Jhong1,Ho Yu-Lin2,Huang Shyh-Shyun1,Chang Heng-Yuan3,Chang Yuan-Shiun14

Affiliation:

1. Institute of Chinese Pharmaceutical Sciences, College of Pharmacy, China Medical University, Taichung 40402, Taiwan

2. Department of Nursing, Hungkuang University, Taichung 433, Taiwan

3. Applied Gerontology, Department of Human Ecology, ToKo University, Chia-Yi 610, Taiwan

4. Chinese Crude Drug Pharmacy, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan

Abstract

Crossostephium chinensis (L.) (CC) Makino is a common traditional Chinese medicinal plant used to dehumidify and cure rheumatism and arthralgia. The water and methanol extracts of C. chinensis (CCW and CCM) were evaluated for their antioxidant and antiproliferative activities. The antioxidant activities of CC were evaluated by using ABTS radical scavenging, DPPH radical scavenging, nitric oxide scavenging and superoxide scavenging methods. Iron chelating activity, lipid peroxidation, total polyphenol contents, total flavonoid contents and total flavonol contents were also detected. In all the tested models, both CCW and CCM showed their ability to scavenge the free radicals in a does-dependent manner. CCW had higher antioxidant and antiproliferative activities than CCM. In LC-MS-MS analysis, the chromatograms of CCW with good antioxidant activities were established. Rutin might be an important bioactive compound in CCW. The antiproliferative activities of CCW and CCM were also studied in vitro by using human hepatoma HepG2 cells. CCW exhibited good antiproliferative activity. These results indicated that CCW might be used as a potential source of natural antioxidants and as an anti-tumor agent.

Publisher

World Scientific Pub Co Pte Lt

Subject

Complementary and alternative medicine,General Medicine

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