Gates joint locally connected network for accurate and robust reconstruction in optical molecular tomography
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Published:2023-11-04
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Volume:
Page:
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ISSN:1793-5458
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Container-title:Journal of Innovative Optical Health Sciences
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language:en
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Short-container-title:J. Innov. Opt. Health Sci.
Author:
Zhao Minghua1ORCID,
Xiao Yahui1ORCID,
Zhang Jiaqi1ORCID,
Cao Xin2ORCID,
Wang Lin1ORCID
Affiliation:
1. School of Computer Science and Engineering, Xi’an University of Technology, Xi’an, China
2. School of Information Science and Technology, Northwest University, Xi’an 710127, China
Abstract
Optical molecular tomography (OMT) is a potential pre-clinical molecular imaging technique with applications in a variety of biomedical areas, which can provide non-invasive quantitative three-dimensional (3D) information regarding tumor distribution in living animals. The construction of optical transmission models and the application of reconstruction algorithms in traditional model-based reconstruction processes have affected the reconstruction results, resulting in problems such as low accuracy, poor robustness, and long-time consumption. Here, a gates joint locally connected network (GLCN) method is proposed by establishing the mapping relationship between the inside source distribution and the photon density on surface directly, thus avoiding the extra time consumption caused by iteration and the reconstruction errors caused by model inaccuracy. Moreover, gates module was composed of the concatenation and multiplication operators of three different gates. It was embedded into the network aiming at remembering input surface photon density over a period and allowing the network to capture neurons connected to the true source selectively by controlling three different gates. To evaluate the performance of the proposed method, numerical simulations were conducted, whose results demonstrated good performance in terms of reconstruction positioning accuracy and robustness.
Funder
National Natural Science Foundation of China
Key Research and Development Projects of Shaanxi Province
Publisher
World Scientific Pub Co Pte Ltd
Subject
Biomedical Engineering,Atomic and Molecular Physics, and Optics,Medicine (miscellaneous),Electronic, Optical and Magnetic Materials