MAGNETIC NANOPARTICLE HYPERTHERMIA IN CANCER TREATMENT

Author:

GIUSTINI ANDREW J.1,PETRYK ALICIA A.2,CASSIM SHIRAZ M.2,TATE JENNIFER A.2,BAKER IAN2,HOOPES P. JACK1

Affiliation:

1. Dartmouth Medical School and the Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA

2. Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA

Abstract

The activation of magnetic nanoparticles (mNPs) by an alternating magnetic field (AMF) is currently being explored as technique for targeted therapeutic heating of tumors. Various types of superparamagnetic and ferromagnetic particles, with different coatings and targeting agents, allow for tumor site and type specificity. Magnetic nanoparticle hyperthermia is also being studied as an adjuvant to conventional chemotherapy and radiation therapy. This review provides an introduction to some of the relevant biology and materials science involved in the technical development and current and future use of mNP hyperthermia as clinical cancer therapy.

Publisher

World Scientific Pub Co Pte Lt

Subject

General Medicine

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