Affiliation:
1. Department of Gastroenterology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, P. R. China
2. Institute of Digestive Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, P. R. China
Abstract
Several functional gastrointestinal disorders (FGIDs) have overlapping symptoms, and, consequently, developing treatment strategies based on symptomatology poses a challenge for the clinical management of complex FGIDs. The significant overlap in the symptoms of FGIDs caused by the shared pathophysiological mechanisms is both a challenge and an excellent target for therapeutic development, since treatment strategies focused on shared pathophysiological mechanisms can treat the associated underlying diseases rather than just alleviating the primary symptoms. Owing to its multi-targeted approach, traditional Chinese medicine (TCM) has garnered immense interest worldwide; however, the quality of the data demonstrating its effectiveness is generally weak. Additionally, the causal link between the intrinsic mechanisms of action of TCM and its clinical benefits remains obscure. Systems biology is characterized by holistic and dynamic research, which corresponds to the holistic, multi-targeted, and syndrome-based approach of TCM. Therefore, high-throughput analysis techniques can be employed to describe and comprehend the genesis and progression of diseases, as well as the impacts of TCM on the organism, which may aid in elucidating the pathogenic mechanisms of the diseases as well as the mechanism of action of TCM.
Funder
the National Key R&D Program in the thirteenth Five-year Plan
the Chinese Ministry of Science and Technology, State Administration of Traditional Chinese Medicine Digestive Refractory Disease Inheritance and Innovation Team Project
National Natural Science Foundation of China
China Academy of Chinese Medical Sciences Innovation Fund
China Academy of Chinese Medical Sciences Excellent Young Talent Cultivation Fund
Publisher
World Scientific Pub Co Pte Ltd
Subject
Complementary and alternative medicine,General Medicine
Cited by
2 articles.
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