Thymoquinone Induces Apoptosis in Oral Cancer Cells Through P38β Inhibition


Abdelfadil Ehab12,Cheng Ya-Hsin3,Bau Da-Tian4,Ting Wei-Jen1,Chen Li-Mien56,Hsu Hsi-Hsien7,Lin Yueh-Min89,Chen Ray-Jade10,Tsai Fu-Jenn11,Tsai Chang-Hai12,Huang Chih-Yang11113


1. Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan

2. Oral and Maxillofacial Department, Faculty of Dentistry, Department of Surgical Oncology, Oncology Center, Mansoura University, Egypt

3. Department of Physiology, School of Medicine, China Medical University, Taichung, Taiwan

4. Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan

5. Center of General Education, Central Taiwan University of Science and Technology, Taichung, Taiwan

6. Department of Internal Medicine, Armed Force Taichung General Hospital, Taichung, Taiwan

7. Division of Colorectal Surgery, Mackay Memorial Hospital, Taipei, Taiwan

8. Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan

9. Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan

10. Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

11. Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan

12. Department of Healthcare Administration, Asia University, Taiwan

13. Department of Health and Nutrition Biotechnology, Asia University, Taiwan


Oral cancer is a common malignancy associated with high morbidity and mortality. While p38 MAPK is reported to be involved in different cellular activities such as proliferation and differentiation, reports rarely define the roles of the individual members of the p38 MAPK family in cancer. We used two unique cell lines developed by our lab representing chemically induced oral cancer cells (T28) and non-tumor cells (N28) obtained from tissues surrounding the induced cancer as a model to screen out whether p38 MAPK is involved in the malignant transformation processes. The results suggest an association between p38β not p38α and oral cancer development. Additionally, the anti-cancer activity of thymoquinone (TQ) was screened out and we found evidences suggesting that the anti-tumor activity of TQ may be attributed to the downregulation of p38β MAPK.


World Scientific Pub Co Pte Lt


Complementary and alternative medicine,General Medicine







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