Curcumin-Pretreated Adipose-Derived Stem Cells Enhance the Neuroprotective Ability to Repair Rheumatoid Arthritis-Induced Damage in the Rat Brain

Author:

Ju Da-Tong1,Tsai Bruce Chi-Kang2,Sitorus Maria Angelina2,Kuo Wei-Wen34,Kuo Chia-Hua5,Chen Tung-Sheng6,Hsieh Dennis Jine-Yuan78,Ho Tsung-Jung91011,Huang Chih-Yang212131415,Wang Chien-Hao1011

Affiliation:

1. Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

2. Cardiovascular and Mitochondrial Related Disease Research Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan

3. Department of Biological Science and Technology, China Medical University, Taichung, Taiwan

4. Ph.D. Program for Biotechnology Industry, China Medical University, Taichung, Taiwan

5. Laboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan

6. School of Life Science, National Taiwan Normal University, Taipei, Taiwan

7. School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan

8. Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan

9. Integration Center of Traditional Chinese and Modern Medicine, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan

10. Department of Chinese Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan

11. School of Post-Baccalaureate Chinese Medicine, College of Medicine, Tzu Chi University, Hualien, Taiwan

12. Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan

13. Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan

14. Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung, Taiwan

15. Center of General Education, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien, Taiwan

Abstract

Neurodegenerative diseases have become increasingly prevalent in the aged population. Rheumatoid arthritis (RA) is an autoimmune disease that causes systemic inflammation, damaging the neurons. However, only a few treatment options can reduce RA-induced neurodegeneration. This study aimed to evaluate whether adipose-derived stem cells (ADSCs) pretreated with curcumin could ameliorate RA-induced neurodegenerative illness in an RA rat model. Wistar rats were randomly classified into the following four groups: control, RA, RA + ADSC (1 × 106 cells per rat), and RA + curcumin-pretreated ADSC (1 × 106 cells per rat). After treatment for two months, the effects were specifically evaluated in the brains collected from the rats. Our results demonstrated that the transplantation of curcumin-pretreated ADSCs substantially reduced inflammation and apoptosis in the cortices of RA rats compared to those of other groups. Thus, the combination of ADSCs and curcumin exerts a synergistic effect in enhancing neuronal protection in RA rats. In the future, this combination therapeutic strategy can potentially be used as a novel treatment method to reduce RA-induced neurodegenerative disorders.

Funder

Tri-Service General Hospital

Ministry of Science and Technology

Hualien Tzu Chi Hospital

China Medical University and Asia University

Publisher

World Scientific Pub Co Pte Ltd

Subject

Complementary and alternative medicine,General Medicine

全球学者库

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"全球学者库"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前全球学者库共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2023 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3