Do NSAIDs and Other Pain Relief Drugs Can Inhibit the Growth of <i>Lactobacillaceae</i>?-Reference-Cited by-同舟云学术

Do NSAIDs and Other Pain Relief Drugs Can Inhibit the Growth of Lactobacillaceae?

Published:2023-12-01 Issue:4 Volume:72 Page:507-513
ISSN:2544-4646
Container-title:Polish Journal of Microbiology
language:en
Short-container-title:

Author:

Kruszewska Hanna¹^ORCID,Zawistowska-Rojek Anna¹^ORCID,Tyski Stefan¹^ORCID

Affiliation:

1. Department of Antibiotics and Microbiology, National Medicines Institute , Warsaw , Poland

Abstract

Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) commonly used in clinical practice may cause gastrointestinal injuries and influence the gut microbiota. This study investigated the effects of various NSAIDs and some analgesics on the viability of Lactobacillaceae strains (including probiotic strains) in vitro. It was found that diclofenac, ibuprofen, ketoprofen, dexketoprofen, flurbiprofen, and acetylsalicylic acid inhibited the growth of lactobacilli at a concentration of 0.05−3.2 mg/ml. These MICs of NSAIDs are well above therapeutic plasma concentrations achieved in humans, indicating that the tested drugs should not inhibit the growth of lactobacilli in the human digestive tract.

Publisher

Polish Society of Microbiologists

Subject

Microbiology (medical),Applied Microbiology and Biotechnology,General Medicine,Microbiology

Link

https://www.sciendo.com/pdf/10.33073/pjm-2023-038

Reference50 articles.

1. Aronson JK. Meyler’s side effects of drugs (sixteenth edition). The international encyclopedia of adverse drug reactions and interactions. Dexketoprofen. Oxford (UK): Elsevier; 2016. p. 888–890. https://doi.org/10.1016/B978-0-444-53717-1.01685-1

2. Bacchi S, Palumbo P, Sponta A, Coppolino MF. Clinical pharmacology of non-steroidal anti-inflammatory drugs: a review. Anti-inflamm Antiallergy Agents Med Chem. 2012;11(1):52–64. https://doi.org/10.2174/187152312803476255

3. Bjarnason I, Scarpignato C, Holmgren E, Olszewski M, Rainsford KD, Lanas A. Mechanisms of damage to the gastrointestinal tract from nonsteroidal anti-inflammatory drugs. Gastroenterology. 2018 Feb;154(3):500–514. https://doi.org/10.1053/j.gastro.2017.10.049

4. Blaabjerg S, Artzi DM, Aabenhus R. Probiotics for the prevention of antibiotic-associated diarrhea in outpatients – A systematic review and meta-analysis. Antibiotics. 2017 Oct;6(4):21. https://doi.org/10.3390/antibiotics6040021

5. Caillé G, Besner JG, Lacasse Y, Vézina M. Pharmacokinetic characteristics of ketoprofen suppositories. Biopharm Drug Dispos. 1980 Apr–Jun;1(4):195–201. https://doi.org/10.1002/bdd.2510010407