The role of NETosis in the pathogenesis of immunoinflammatory rheumatic diseases-Reference-Cited by-同舟云学术

The role of NETosis in the pathogenesis of immunoinflammatory rheumatic diseases

Published:2023-10-27 Issue:5 Volume:61 Page:513-530
ISSN:1995-4492
Container-title:Rheumatology Science and Practice
language:
Short-container-title:Naučno-praktičeskaâ revmatologiâ

Author:

Nasonov E. L.¹^ORCID,Avdeeva A. S.²^ORCID,Reshetnyak T. M.²^ORCID,Aleksankin A. P.²^ORCID,Rubtsov Yu. P.³^ORCID

Affiliation:

1. V.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University)

2. V.A. Nasonova Research Institute of Rheumatology

3. Shemyakin–Ovchinnikov Institute of Bioorganic Chemitry of the Russian Academy of Sciences; National Medical Research Center for Oncology named after N.N. Blokhin

Abstract

Uncontrolled activation of neutrophils is considered an important mechanism of thromboinflammation and fibrosis in immunemediated rheumatic diseases (IMRD), malignant neoplasms, atherosclerosis, COVID-19 and many other acute and chronic inflammatory diseases of humans. Particular attention has been drawn to the ability of neutrophils to form “network” (web-like) structures, called “neutrophil extracellular traps” NETs. The process associated with the formation of NETs and the weakening of their degradation is called “NETosis”. The publication summarizes data on the role of NETosis in the pathogenesis of IMRD and discusses the prospects for pharmacotherapy aimed at preventing the formation and destruction of NETs.

Publisher

Mediar Press

Subject

Immunology,Immunology and Allergy,Rheumatology

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