Affiliation:
1. Research Institute of Applied Biology
2. Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology
3. Research Institute of Applied Biology;
Centre International de Recherche sur les Infections Tropicales en Guinée, Republic of Guinea / International Research Center on Tropical Infections in the Republic of Guinea
4. Federal Research Institute of Viral Infections “Virom”
Abstract
The aim of the work was to estimate the prevalence of HIV, HBV and HCV markers among pregnant women and their male partners in the Republic of Guinea.Materials and methods. The material of the study was blood plasma samples from 140 pregnant women living in Kindia prefecture and N’Zerekore prefecture, as well as 60 male partners who reported sexual contact with HIV-infected persons. The samples were examined for the presence of serological (HBsAg, HBeAg, antibodies anti-HBs IgG, anti-HBcore IgG, anti-HBe IgG, anti-HCV IgG, Ag/Ab-HIV) and molecular (HBV DNA, HCV RNA, HIV RNA) markers.Results and discussion. The age of the examined pregnant women ranged from 13 to 55 years and was on average (26.29±9.67) years. The age of men varied from 15 to 60 years, on average – (29.05±11.99) years. When assessing the prevalence of serological markers, antibodies to HCV were detected in 2.14 % cases in women and in 3.33 % cases in men. Antibodies to HIV were found in 6.43 % and 6.67 % women and men, respectively. Serological markers associated with HBV were detected in 80.71 % (HBsAg – 13.57 %) of women and 81.67 % (15 %) of men. In the pregnant women, HCV RNA was not detected, HIV RNA was revealed in 1 case, HBV DNA was identified in 26 cases (18.57 %), including 5 % HBsAg-negative hepatitis B cases. In the men group, HCV RNA and HIV RNA were detected in 3.33 % and 6.67 % cases, respectively. HBV DNA was determined in 16.67 % of men, including latent hepatitis B in one person. A significantly higher incidence of HIV in men compared to women is shown (χ2=3.907 at p<0.05). The relative risk of HIV infection in men is nine times higher than in women: RR=9.333; p=0.0291; 95 % CI: 1.065–81.815 %. Four out of five identified HIV infection cases were co-infected with HBV and/or HCV. There is an obvious need to introduce screening for HIV, HCV, HBV, including latent hepatitis B, into routine laboratory diagnostics during examination of pregnant women and their partners, followed by couples counseling and vaccination against hepatitis B virus.
Publisher
Russian Research Anti-Plague Institute Microbe
Subject
Infectious Diseases,Microbiology (medical),Immunology,Microbiology,Epidemiology
Reference31 articles.
1. World Health Organization. Hepatitis B. Key facts. (Cited 08 Sept 2022). [Internet]. Available from: http://www.who.int/newsroom/fact-sheets/detail/hepatitis-b.
2. World Health Organization. Hepatitis C. Key facts. (Cited 08 Sept 2022). [Internet]. Available from: https://www.who.int/newsroom/fact-sheets/detail/hepatitis-c.
3. World Health Organization. HIV. Key facts. (Cited 08 Sept 2022). [Internet]. Available from: https://cdn.who.int/media/docs/default-source/hq-hiv-hepatitis-and-stis-library/key-facts-hiv-2020.pdf?sfvrsn=582c3f6e_3.
4. Raizada A., Dwivedi S., Bhattacharya S. The hepatitis B, hepatitis C and HIV co-infection at an antiretroviral centre in Delhi. Trop. Doct. 2011; 41(3):154–6. DOI: 10.1258/td.2011.100440.
5. Degenhardt L., Charlson F., Stanaway J., Larney S., Alexander L.T., Hickman M., Cowie B., Hall W.D., Strang J., Whiteford H., Vos T. Estimating the burden of disease attributable to injecting drug use as a risk factor for HIV, hepatitis C, and hepatitis B: findings from the Global Burden of Disease Study 2013. Lancet Infect. Dis. 2016; 16(12):1385–98. DOI: 10.1016/S1473-3099(16)30325-5.