Affiliation:
1. İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA
Abstract
A new complex with composition [Ni(L)(PPh3)] (PPh3 = triphenylphosphine) was obtained from the reaction of 1,5-bis(salicylidene)thiocarbohydrazone (L) with an equimolar amount of [NiCl2(PPh3)2]. The complex was identified by FT-IR, 1H NMR and UV-Vis spectroscopic methods and elemental analysis. The solid state structure of [Ni(L)(PPh3)] was established by X-ray diffraction analysis. It was determined that the complex, whose nickel center has a distorted square planar configuration, crystallizes in the monoclinic space group I2/c. Bisthiocarbohydrazone (L) binds to the nickel center through its phenolate O, azomethine N and thioenolate S atoms in a dianionic tridentate mode. The antioxidant capacity of L and Ni(II) complex was examined using the CUPRAC (cupric reducing antioxidant capacity) method. Also, the DPPH (1,1-Diphenyl-2-picrylhydrazyl) method was used to test free radical scavenging activity of the compounds. Antioxidant activity results showed that L exhibited better activity than Ni(II) complex.
Reference39 articles.
1. [1] Reddy B.N., Avaji P.G., Badami P.S., Patil S.A., Synthesis, spectral and biological studies of cobalt(II), nickel(II) and copper(II) complexes with 1,5-bis (thiophenylidene) thiocarbohydrazone, J. Saudi Chem. Soc., 11 (2) (2007) 253-268.
2. [2] Sathisha M.P., Shetti U.N., Revankar V.K., Pai K.S.R., Synthesis and antitumor studies on novel Co(II), Ni(II) and Cu(II) metal complexes of bis(3-acetylcoumarin) thiocarbohydrazone, Eur. J. Med. Chem., 43 (11) (2008) 2338-2346.
3. [3] Chee D.N.A., Affan M.A., Ahmad F.B., Asaruddin M.R., Sam N., Salam M.A., Ismail A., Tan S.H., Synthesis, characterization, and antibacterial activity of organotin(IV) complexes with 2-hydroxyacetophenone thiocarbohydrazone, J. Coord. Chem., 64 (23) (2011) 4191-4200.
4. [4] Metwally M.A., Khalifa M.E., Koketsu M., Thiocarbohydrazides: Synthesis and reactions, Am. J. Chem., 2 (2) (2012) 38-51.
5. [5] Kaya Y., Erçağ A., Koca A., Synthesis, structures, electrochemical studies and antioxidant activities of cis-dioxomolybdenum(VI) complexes of the new bisthiocarbohydrazones, J. Mol. Struct., 1102 (2015) 117-126.