Author:
Ornitz David M.,Marie Pierre J.
Abstract
Fibroblast growth factor (FGF) signaling pathways are essential regulators of vertebrate skeletal development. FGF signaling regulates development of the limb bud and formation of the mesenchymal condensation and has key roles in regulating chondrogenesis, osteogenesis, and bone and mineral homeostasis. This review updates our review on FGFs in skeletal development published in Genes & Development in 2002, examines progress made on understanding the functions of the FGF signaling pathway during critical stages of skeletogenesis, and explores the mechanisms by which mutations in FGF signaling molecules cause skeletal malformations in humans. Links between FGF signaling pathways and other interacting pathways that are critical for skeletal development and could be exploited to treat genetic diseases and repair bone are also explored.
Funder
National Institutes of Health
Institut National de la Recherche Médicale
University Paris Diderot Sorbonne Paris Cité
DIM Stem Pôle Ile de France
French Minister of Research
Asssociation Prévention et Traitement des Décalcifications
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics
Cited by
287 articles.
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