Initial clinical evidence on biperiden as antiepileptogenic after traumatic brain injury. A Randomized Clinical Trial

Abstract

AbstractThere is currently no available drug to prevent the development of post-traumatic epilepsy. insufficient evidence regarding the effect of biperiden in preventing post-traumatic epilepsy after TBI. The combined effect of variables known to have an impact on the likelihood of developing late post-traumatic seizures and its unbalanced frequency in the different groups is an aspect to be considered and underpins the need for larger studies.HighlightsPrior research suggests anticholinergics may prevent post-traumatic epilepsyThere was insufficient evidence on biperiden’s role in preventing PTE after TBIVariable impact on post-traumatic epilepsy underscores need for broader studiesGraphical Abstract