Cold adaptation in Upper Paleolithic hunter-gatherers of eastern Eurasia
Author:
Watanabe Yusuke, Wakiyama Yoshiki, Waku Daisuke, Valverde Guido, Tanino Akio, Nakamura Yuka, Suzuki Tsubasa, Koganebuchi Kae, Gakuhari Takashi, Katsumura TakafumiORCID, Ogawa Motoyuki, Toyoda AtsushiORCID, Mizushima Soichiro, Nagaoka Tomohito, Hirata Kazuaki, Yoneda Minoru, Nishimura Takayuki, Izuho Masami, Yamada Yasuhiro, Masuyama Tadayuki, Takahashi Ryuzaburo, Ohashi Jun, , Oota Hiroki
Abstract
ABSTRACTPrevious genomic studies understanding the dispersal ofHomo sapienshave suggested that present-day East Eurasians and Native Americans can trace their ancestry to migrations from Southeast Asia. However, ineluctable adaptations during the Last Glacial Maximum (LGM) remain unclear. By analyzing 42 genomes of up to 30-fold coverage from prehistoric hunter-gatherers, Jomon, we reveal their descent from Upper Paleolithic (UP) foragers who migrated to and isolated in the Japanese archipelago during Late Pleistocene. We provide compelling evidence suggesting that these UP people underwent positive selection for cold environments, aiding their survival through the LGM facilitated by non-shivering thermogenesis and detecting it polygenically across multiple loci in the Jomon lineage. Our study pioneers the close estimation of the physiological adaptation of ancient humans by the paleogenomic approach.
Publisher
Cold Spring Harbor Laboratory
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