Abstract
ABSTRACTThe aim of this systematic review and meta-analysis was to identify a list of common, candidate genes associated with the three components of fitness, specifically cardiovascular fitness, muscular strength, and anaerobic power, and how these genes are associated with exercise response phenotype variability, in previously untrained participants. A total of 3,969 potentially relevant papers were identified and processed for inclusion. After eligibility and study selection assessment, 24 studies were selected for meta-analysis, comprising a total of 3,012 participants. Meta-Essentials spreadsheet 1.4 (Microsoft Excel) was used in creating the forest plots and meta-analysis. IBM SPSS statistics V24 was implemented for the statistical analyses and the alpha was set at p ≤ 0.05. 13 candidate genes and their associated alleles were identified, which were associated with the phenotypes of interest. Analysis of training group data showed significant differential phenotypic responses. Subgroup analysis showed; 44%, 72% and 10% of the response variance in aerobic, strength and power phenotypes, respectively, were explained by genetic influences. This analysis established that genetic variability explained a significant proportion of the adaptation differences across the three components of fitness in the participants post-training. The results also showed the importance of analysing and reporting specific gene alleles. Information obtained from these findings has the potential to inform and influence future exercise-related genes and training studies.
Publisher
Cold Spring Harbor Laboratory
Reference93 articles.
1. Association analysis of ACE, ACTN3 and PPARGC1A gene polymorphisms in two cohorts of European strength and power athletes
2. Individual differences in the responses to endurance and resistance training
3. Metzl J. ACSM Blogs. 2017 May 16. [Cited 1 December 2020] In: ACSM Blogs [internet]. American college of sports and exercise 2020 - [Exercise guidelines] Available from: https://www.acsm.org/all-blog-posts/acsm-blog/acsm-blog/2017/05/16/science-of-exercise
4. Applications of the dose-response for muscular strength development: areview of meta-analytic efficacy and reliability for designing training prescription;The Journal of Strength & Conditioning Research,2005
5. Ratamess NA . ACSM’s foundations of strength training and conditioning. Wolters Kluwer Health/Lippincott Williams & Wilkins; 2012.