A new method of Non-Ultrasound Monitoring of Ovarian Stimulation (NUMOS): Mission Possible! - a pilot study

Author:

Vladimirov Iavor K.ORCID,Tacheva Desislava,Gatev Evan,Rangelova Magdalena,Vladimirov Martin

Abstract

AbstractPurposeThis study aims to establish the viability of monitoring an appropriate and safe ovarian stimulation without the use of ultrasound and serum hormone testing.MethodAs a primary marker for monitoring of the ovarian response, we used urinary estrone-3-glucuronide (E1-3G) growth rate, which was self-measured by patients daily at home, with a portable analyzer, during the stimulation. For an adequate ovarian response, an average daily rate of increase of E1-3G was estimated to be within 25 - 77%. Ovulation trigger day was determined based on the length of the menstrual cycle.The study included 24 women. Inclusion criteria were age < 41 years and AMH >1 ng/mL. A progestin-primed ovarian stimulation protocol (PPOS) with fixed doses of gonadotropins was used.ResultsThe average female age was 32,9 years (±4.4), BMI 22,7 kg/m2 (±4,3), AMH 3,7 ng/ml (±2,6), stimulation days 10,6 (±1,1), collected oocytes 12,5 (±8,5), MII oocytes 10,6 (±7,8), fertilization rate 83,6% (±22,5), blastocyst 66,4% (±28,6), good quality blastocysts 31,6% (±16,9).Absence of oocyte aspiration was found in one of the cases. There were no cases of OHSS and ovarian stimulation cancellation.ConclusionThis is the first pilot study to successfully apply a new markers for ovarian stimulation monitoring.

Publisher

Cold Spring Harbor Laboratory

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