Author:
Krasnovskaya Olga,Abramchuk Daniil,Vaneev Alexander,Gorelkin Peter,Abakumov Maxim,Timoshenko Roman,Chmelyuk Nelly,Vadekhina Veronika,Kuanaeva Regina,Dubrovin Evgeniy V.,Kolmogorov Vasilii,Beloglazkina Elena,Erofeev Alexander
Abstract
Alz-5 acts as a bifunctional chelator that can interact with various Aβ aggregates and reduce their neurotoxicity. Single-cell ROS measurements provided by Pt-nanoelectrode technique revealed a significant antioxidant properties of Alz-5 in Aβ42- affected SH-SY5Y cell. AFM data obtained on Aβ42fibrils clearly indicate an anti-aggregating property of Alz-5. Young’s modulus mapping on living SH-SY5Y cells revealed an ability of Alz-5 to decrease cell rigidity in Aβ42- affected SH-SY5Y cells.
Publisher
Cold Spring Harbor Laboratory