SUPERVISED WHITE MATTER BUNDLE SEGMENTATION IN GLIOMA PATIENTS WITH TRANSFER LEARNING

Abstract

ABSTRACTIn clinical neuroscience, the segmentation of the main white matter bundles is propaedeutic for many tasks such as pre-operative neurosurgical planning and monitoring of neuro-related diseases. Automating bundle segmentation with data-driven approaches and deep learning models has shown promising accuracy in the context of healthy individuals. The lack of large clinical datasets is preventing the translation of these results to patients. Inference on patients’ data with models trained on healthy population is not effective because of domain shift. This study aims to carry out an empirical analysis to investigate how transfer learning might be beneficial to overcome these limitations. For our analysis, we consider a public dataset with hundreds of individuals and a clinical dataset with several tens of glioma patients. We focus our preliminary investigation on the corticospinal tract. The results show that transfer learning might be effective in partially overcoming the domain shift.