Plasticity in inhibitory networks improves pattern separation in early olfactory processing

Abstract

AbstractDistinguishing between nectar and non-nectar odors presents a challenge for animals due to shared compounds in complex mixtures, where changing ratios often signify differences in reward. Changes in nectar production throughout the day and potentially many times within a forager’s lifetime add to the complexity. The honeybee olfactory system, containing less than a 1000 of principal neurons in the early olfactory relay, the antennal lobe (AL), must learn to associate diverse volatile blends with rewards. We used a computational network model and live imaging of the honeybee’s AL to explore the neural mechanisms and functions of the AL plasticity. Our findings revealed that when trained with a set of rewarded and unrewarded odors, the AL inhibitory network suppresses shared chemical compounds while enhancing responses to distinct compounds. This results in improved pattern separation and a more concise and efficient neural code. Our Ca2+imaging data support our model’s predictions. Furthermore, we applied these contrast enhancement principles to a Graph Convolutional Network (GCN) and found that similar mechanisms could enhance the performance of artificial neural networks. Our model provides insights into how plasticity at the inhibitory network level reshapes coding for efficient learning of complex odors.