Temporal microstructure of dyadic social behavior during relationship formation in mice

Author:

Lee Won,Fu Jiayi,Bouwman Neal,Farago Pam,Curley James P.ORCID

Abstract

AbstractUnderstanding the temporal dynamics of how unfamiliar animals establish dominant-subordinate relationships and learn to modify their behavior in response to their social partner in context-appropriate manners is critical in biomedical research concerning social competence. Here we observe and analyze the microstructure of social and non-social behaviors as 21 pairs of outbred CD-1 male mice (Mus Musculus) establish dominant-subordinate relationships during daily 20-minute interaction for five consecutive days. Using Kleinberg burst detection algorithm, we demonstrate aggressive and subordinate interactions occur in bursting patterns followed by quiescence period rather than in uniformly distributed across social interactions. Further, we identify three phases of dominant-subordinate relationship development (pre-, middle-, and post-resolution) by combining phi-coefficient and difference methods used to determine at which bursting event mice resolve dominant-subordinate relationships. Using First Order Markov Chains within individuals we show dominant and subordinate animals establish significantly different behavioral repertoire once they resolve the relationships. In both dominant and subordinate mice, the transitions between investigative and agonistic behavior states are not common. Lastly, we introduce Forward Spike Time Tiling Coefficient, the strength of association between the given behavior of one individual with the target behavior of the other individual within a specified time window. With this method, we describe the likelihood of a mouse responding to a behavior with another behavior differ in pre- and post-resolution phases. The data suggest that subordinate mice learn to exhibit subordinate behavior in response to dominant partner’s behaviors while dominant mice become less likely to show subordinate behaviors in response to their partners’ action. Overall, with the tool we present in this study, the data suggest CD-1 male mice are able to establish dominance relationships and modify their behaviors even to the same social cues under different social contexts competently.

Publisher

Cold Spring Harbor Laboratory

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3