Aberrant brain-type neuronal programs in large-cell pancreatic neuroendocrine carcinoma-Reference-Cited by-同舟云学术

Aberrant brain-type neuronal programs in large-cell pancreatic neuroendocrine carcinoma

Published:2025-06-24 Issue: Volume: Page:
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Author:

Debnath Olivia^ORCID,Berger Hilmar^ORCID,Detjen Katharina,Kirchner Philipp^ORCID,Mariononi Ilaria^ORCID,Eichhorn Ines,Bolduan Felix^ORCID,Conrad Thomas^ORCID,Horst David^ORCID,Eils Roland^ORCID,Wiedenmann Bertram^ORCID,Perren Aurel^ORCID,Ishaque Naveed^ORCID

Abstract

AbstractHigh-grade pancreatic neuroendocrine carcinoma (panNEC) is a rare, aggressive cancer with limited tissue availability. Single-nucleus transcriptomics of five large-cell panNECs revealed two clinically relevant neuroendocrine cell states: one highly proliferative with an aberrant brain-specific neuronal differentiation program and another stress-responsive state enriched for heat stress, hypoxia, and glycolysis. Our findings suggest potentially new therapeutic vulnerabilities, highlighting the need to evaluate the efficacy of combination therapies.

Publisher

Cold Spring Harbor Laboratory

Reference42 articles.

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