Abstract
Imprinted gene clusters are confined genomic regions containing genes with parent-of-origin-dependent transcriptional activity. In this issue ofGenes & Development, Loftus and colleagues (pp. 829–843) made use of an insightful combination of descriptive approaches, genetic manipulations, and epigenome-editing approaches to show that differences in nuclear topology precede the onset of imprinted expression at thePeg13-Kcnk9locus. Furthermore, the investigators provide data in line with a model suggesting that parent-of-origin-specific topological differences could be responsible for parent-of-origin-specific enhancer activity and thus imprinted expression.
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics