Infant attachment does not depend on neonatal amygdala and hippocampal structure and connectivity

Abstract

AbstractInfant attachment is an antecedent of later socioemotional abilities, which can be adversely affected by preterm birth. The structural integrity of amygdalae and hippocampi are associated with attachment in childhood. We aimed to investigate associations between neonatal amygdalae and hippocampi structure and their whole-brain connections and attachment behaviours at nine months of age in a sample of infants enriched for preterm birth. In 133 neonates (median gestational age 32 weeks, range 22.14–42.14), we calculated measures of amygdala and hippocampal structure (volume, fractional anisotropy, mean diffusivity, neurite dispersion index, orientation dispersion index) and structural connectivity, and coded attachment behaviours (distress, fretfulness, attentiveness to caregiver) from responses to the Still-Face Paradigm at nine months. After multiple comparisons correction, there were no significant associations between neonatal amygdala or hippocampal structure and structural connectivity and attachment behaviours: standardised β values -0.23 to 0.21, adjusted p-values > 0.34. Findings indicate that the neural basis of infant attachment in term and preterm infants is not contingent on the structure or connectivity of the amygdalae and hippocampi in the neonatal period, which implies that it is more widely distributed in early life and or that network specialisation takes place in the months after hospital discharge.Highlights133 infants had brain MRI and attachment data based on the Still-Face Paradigm.The structure of amygdalae and hippocampi and their brain networks was examined.Neonatal amygdalae/hippocampi structure did not associate with infant attachment.Infant attachment is not contingent on neonatal amygdala/hippocampal connectivity.Graphical abstract