Abstract
ABSTRACTSchizophrenia, Schizoaffective, and Bipolar Disorders share common illness traits, intermediate phenotypes and a partially overlapping polygenic basis. We performed GWAS on deep phenotyping data, including structural MRI and DTI, clinical, and behavioral scales from 1,115 cases and controls. Significant associations were observed with two cerebrospinal fluid volumes: the temporal horn of left lateral ventricle was associated withNRXN1, and the volume of the cavum septum pellucidum was associated withLRP1BandRORA. Both volumes were associated with illness. Suggestive associations were observed with local gyrification indices, fractional anisotropy and age at onset. The deep phenotyping approach allowed unexpected genetic sharing to be found between phenotypes, including temporal horn of left lateral ventricle and age at onset.
Publisher
Cold Spring Harbor Laboratory
Reference72 articles.
1. Biological insights from 108;Schizophrenia Working Group of the Psychiatric Genomics, C.;Schizophrenia-associated genetic loci. Nature,2014
2. A multiple-phenotype imputation method for genetic studies
3. The Effects of FreeSurfer Version, Workstation Type, and Macintosh Operating System Version on Anatomical Volume and Cortical Thickness Measurements
4. Bipolar and;Schizophrenia network for intermediate phenotypes: outcomes across the psychosis continuum. Schizophr Bull,2014