Anti-chemokine antibodies after SARS-CoV-2 infection correlate with favorable disease course
Author:
Muri JonathanORCID, Cecchinato ValentinaORCID, Cavalli AndreaORCID, Shanbhag Akanksha A.ORCID, Matkovic MilosORCID, Biggiogero Maira, Maida Pier Andrea, Moritz JacquesORCID, Toscano ChiaraORCID, Ghovehoud ElahehORCID, Furlan Raffaello, Barbic Franca, Voza Antonio, Nadai Guendalina De, Cervia Carlo, Zurbuchen YvesORCID, Taeschler Patrick, Murray Lilly A., Danelon-Sargenti Gabriela, Moro SimoneORCID, Gong TaoORCID, Piffaretti PietroORCID, Bianchini FilippoORCID, Crivelli VirginiaORCID, Podešvová LucieORCID, Pedotti MattiaORCID, Jarrossay DavidORCID, Sgrignani JacopoORCID, Thelen Sylvia, Uhr Mario, Bernasconi EnosORCID, Rauch AndriORCID, Manzo AntonioORCID, Ciurea AdrianORCID, Rocchi Marco B.L.ORCID, Varani LucaORCID, Moser Bernhard, Bottazzi Barbara, Thelen MarcusORCID, Fallon Brian A., Boyman Onur, Mantovani Alberto, Garzoni Christian, Franzetti-Pellanda Alessandra, Uguccioni MariagraziaORCID, Robbiani Davide F.ORCID
Abstract
AbstractInfection by SARS-CoV-2 leads to diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors are associated with adverse COVID-19 outcomes. Instead, we discovered that antibodies against specific chemokines are omnipresent after COVID-19, associated with favorable disease, and predictive of lack of long COVID symptoms at one year post infection. Anti-chemokine antibodies are present also in HIV-1 infection and autoimmune disorders, but they target different chemokines than those in COVID-19. Monoclonal antibodies derived from COVID- 19 convalescents that bind to the chemokine N-loop impair cell migration. Given the role of chemokines in orchestrating immune cell trafficking, naturally arising anti-chemokine antibodies associated with favorable COVID-19 may be beneficial by modulating the inflammatory response and thus bear therapeutic potential.One-Sentence Summary:Naturally arising anti-chemokine antibodies associate with favorable COVID-19 and predict lack of long COVID.
Publisher
Cold Spring Harbor Laboratory
Cited by
3 articles.
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