Skin Sensitisation Case Study: Comparison of Defined Approaches including OECD 497 Guidance

Author:

Ankli Pascal P.,Parween Shaheena,Lopez Béatrice,Daligaux Pierre,Mohorič Tomaž,Darde Thomas,Chesné Christophe,Stockman Nathan,Boglári Csaba,Poon Amanda Y.,Hardy BarryORCID

Abstract

AbstractCharacterising known and new chemical compounds for skin sensitisation provides a basis for the development of safer products where ingredients are exposed to skin. By including new approaches, such as tiered testing strategies and integrated data analysis, it is possible to develop next generation products adhering to emerging regulations, scientific evidence and animal welfare principles. To ensure data integrity during such assessment the OECD provides characterisation guidelines and Defined Approaches (DAs) to uniform work-flows. In this study we developed and applied the integrated characterisation tool called «SaferSkin» to compare the results of different DAs for eight compounds and included results obtained from current OECD guidance and emerging methods. We tested two compounds with unclear or indeterminate results with the SENS-IS assay to explore the value of the experiment in strengthening the weight of evidence and arriving at a clearer conclusion.

Publisher

Cold Spring Harbor Laboratory

Reference40 articles.

1. Skin Sensitisation [Internet]. [cited 2023 Apr 27]. Available from: https://joint-research-centre.ec.europa.eu/eu-reference-laboratory-alternatives-animal-testing-eurl-ecvam/alternative-methods-toxicity-testing/validated-test-methods-health-effects/skin-sensitisation_en

2. Mayo Clinic [Internet]. [cited 2023 Apr 27]. Contact dermatitis - Symptoms and causes. Available from: https://www.mayoclinic.org/diseases-conditions/contact-dermatitis/symptoms-causes/syc-20352742

3. In-vitro-Tests zum Nachweis von Kontaktallergien;Hautarzt,2005

4. OECD. Guideline No. 497: Defined Approaches on Skin Sensitisation [Internet]. OECD; 2021 [cited 2023 Apr 26]. (OECD Guidelines for the Testing of Chemicals, Section 4). Available from: https://www.oecd-ilibrary.org/environment/guideline-no-497-defined-approaches-on-skin-sensitisation_b92879a4-en

5. Standardisation and international adoption of defined approaches for skin sensitisation;Front Toxicol,2022

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