Synthesis of Renin Inhibitors Containing a Sulfonemethylene Isostere at TheirN-Terminals
Author:
Publisher
The Chemical Society of Japan
Subject
General Chemistry
Link
https://www.jstage.jst.go.jp/article/cl/19/4/19_4_505/_pdf
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1. A versatile and stereocontrolled synthesis of hydroxyethylene dipeptide isosteres
2. The synthesis of (2S,4S,5S) -5-(N-BOC)-amino-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid lactone, an hydroxyethylene dipeptide isostere precusor
3. Synthesis of the lactone precursor to hydroxyethylene dipeptide isostere from 3,4,6-tri-O-acetyl-D-glucal
4. An efficient synthesis of the γ-lactone corresponding to a hydroxyethylene dipeptide isostere using stereoselective bromolactonisation of a chiral acyloxazolidinone
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