Abstract
The Phase 3 aducanumab program in early AD has been stopped based on a futility efficacy analysis. This huge disappointment follows exciting preliminary studies that had raised expectations (1). Now this frustrating result joins the long series of negative and interrupted trials of potential disease-modifying agents, going back to tarenflurbil (2), tramiprosate (3), and bapineuzumab (4), among many others. Is the amyloid hypothesis wrong? Where do we go from here?
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18 articles.
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