Integrated Bioinformatics Analysis Predicts the Key Genes Involved in Aortic Valve Calcification: From Hemodynamic Changes to Extracellular Remodeling

Author:

Liu Mu12,Luo Ming3,Sun Haoliang3,Ni Buqing3,Shao Yongfeng3

Affiliation:

1. The First Medical School of Nanjing Medical University, Nanjing Medical University

2. School of the Basic Medical Sciences, Nanjing Medical University

3. Department of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University

Publisher

Tohoku University Medical Press

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference65 articles.

1. Albrecht-Schgoer, K., Schgoer, W., Holfeld, J., Theurl, M., Wiedemann, D., Steger, C., Gupta, R., Semsroth, S., Fischer-Colbrie, R., Beer, A.G., Stanzl, U., Huber, E., Misener, S., Dejaco, D., Kishore, R., et al. (2012) The angiogenic factor secretoneurin induces coronary angiogenesis in a model of myocardial infarction by stimulation of vascular endothelial growth factor signaling in endothelial cells. Circulation, 126, 2491-2501.

2. Back, M., Gasser, T.C., Michel, J.B. & Caligiuri, G. (2013) Biomechanical factors in the biology of aortic wall and aortic valve diseases. Cardiovasc. Res., 99, 232-241.

3. Balachandran, K., Sucosky, P. & Yoganathan, A.P. (2011) Hemodynamics and mechanobiology of aortic valve inflammation and calcification. Int. J. Inflam., 2011, 263870.

4. Bosse, Y., Miqdad, A., Fournier, D., Pepin, A., Pibarot, P. & Mathieu, P. (2009) Refining molecular pathways leading to calcific aortic valve stenosis by studying gene expression profile of normal and calcified stenotic human aortic valves. Circ. Cardiovasc. Genet., 2, 489-498.

5. Busnelli, M., Manzini, S., Hilvo, M., Parolini, C., Ganzetti, G.S., Dellera, F., Ekroos, K., Janis, M., Escalante-Alcalde, D., Sirtori, C.R., Laaksonen, R. & Chiesa, G. (2017) Liver-specific deletion of the Plpp3 gene alters plasma lipid composition and worsens atherosclerosis in apoE-/- mice. Sci. Rep., 7, 44503.

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