Mechanisms of action of ribosomally synthesized and posttranslationally modified peptides (RiPPs)

Author:

Cao Li1ORCID,Do Truc1ORCID,Link A James123ORCID

Affiliation:

1. Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA

2. Department of Chemistry, Princeton University, Princeton, NJ 08544, USA

3. Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA

Abstract

Abstract Natural products remain a critical source of medicines and drug leads. One of the most rapidly growing superclasses of natural products is RiPPs: ribosomally synthesized and posttranslationally modified peptides. RiPPs have rich and diverse bioactivities. This review highlights examples of the molecular mechanisms of action that underly those bioactivities. Particular emphasis is placed on RiPP/target interactions for which there is structural information. This detailed mechanism of action work is critical toward the development of RiPPs as therapeutics and can also be used to prioritize hits in RiPP genome mining studies.

Funder

National Institutes of Health

Princeton University School of Engineering and Applied Sciences

National Science Foundation

Publisher

Oxford University Press (OUP)

Subject

Applied Microbiology and Biotechnology,Biotechnology,Bioengineering

Reference258 articles.

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