Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

Author:

Perrino Cinzia1,Barabási Albert-Laszló2345,Condorelli Gianluigi67,Davidson Sean Michael8,De Windt Leon9,Dimmeler Stefanie1011,Engel Felix Benedikt12,Hausenloy Derek John1314151617,Hill Joseph Addison18,Van Laake Linda Wilhelmina1920,Lecour Sandrine21,Leor Jonathan2223,Madonna Rosalinda2425,Mayr Manuel26,Prunier Fabrice27,Sluijter Joost Petrus Geradus28,Schulz Rainer29,Thum Thomas30,Ytrehus Kirsti31,Ferdinandy Péter323334

Affiliation:

1. Department of Advanced Biomedical Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy;

2. Center for Complex Networks Research and Department of Physics, Northeastern University, Boston, MA, USA;

3. Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA;

4. Center for Network Science, Central European University, Budapest, Hungary;

5. Department of Medicine, and Division of Network Medicine, Brigham and Womens Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA;

6. Department of Cardiovascular Medicine, Humanitas Research Hospital and Humanitas University, Rozzano, Italy;

7. Institute of Genetic and Biomedical Research, National Research Council of Italy, Rozzano, Milan, Italy;

8. The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, London, UK;

9. Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER Maastricht, The Netherlands;

10. Institute for Cardiovascular Regeneration, University Frankfurt, Frankfurt, Germany;

11. German Center for Cardiovascular Research (DZHK), RheinMain, Germany;

12. Experimental Renal and Cardiovascular Research, Department of Nephropathology, Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany;

13. The Hatter Cardiovascular Institute, University College London, London, UK;

14. The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK;

15. Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore;

16. National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore;

17. Yong Loo Lin School of Medicine, National University Singapore, Singapore;

18. Departments of Medicine (Cardiology) and Molecular Biology, UT Southwestern Medical Center, Dallas, TX, USA;

19. Division of Heart and Lungs, Hubrecht Institute, University Medical Center Utrecht, Utrecht, The Netherlands;

20. UMC Utrecht Regenerative Medicine Center and Hubrecht Institute, Utrecht, The Netherlands;

21. Hatter Cardiovascular Research Institute, University of Cape Town, Cape Town, South Africa;

22. Neufeld Cardiac Research Institute, Tel-Aviv University, Tel-Aviv, Israel;

23. Tamman Cardiovascular Research Institute, Sheba Medical Center; Sheba Center for Regenerative Medicine, Stem Cell, and Tissue Engineering, Tel Hashomer, Israel;

24. Center of Aging Sciences and Translational Medicine – CESI-MeT, “G. d’Annunzio” University, Chieti, Italy; Institute of Cardiology, Department of Neurosciences, Imaging, and Clinical Sciences, “G. d’Annunzio” University, Chieti, Italy;

25. The Texas Heart Institute and Center for Cardiovascular Biology and Atherosclerosis Research, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA;

26. King's British Heart Foundation Centre, King's College London, London, UK;

27. Department of Cardiology, Institut MITOVASC, University of Angers, University Hospital of Angers, Angers, France;

28. Cardiology and UMC Utrecht Regenerative Medicine Center, University Medical Center Utrecht, Utrecht, The Netherlands;

29. Institute of Physiology, Justus Liebig University Giessen, Giessen, Germany;

30. Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany;

31. Department of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway;

32. Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary;

33. Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Szeged, Hungary;

34. Pharmahungary Group, Szeged, Hungary

Funder

Italian Ministry of Health

National Institute of Health (NIH)

Centers of Excellence of Genomic Science (CEGS)

CardioEpigen

National Research, Development, and Innovation Office

European Research Council

Netherlands Organization for Health Research and Development

Netherlands Heart Foundation

British Heart Foundation

Publisher

Oxford University Press (OUP)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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