Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study-Reference-Cited by-同舟云学术

Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study

Published:2021-01-28 Issue:3 Volume:73 Page:e815-e821
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Hensley Matthew K¹,Bain William G¹²,Jacobs Jana³,Nambulli Sham⁴⁵,Parikh Urvi³,Cillo Anthony⁶⁷,Staines Brittany³,Heaps Amy³,Sobolewski Michele D³,Rennick Linda J⁴⁵,Macatangay Bernard J C³,Klamar-Blain Cynthia³,Kitsios Georgios D¹,Methé Barbara¹,Somasundaram Ashwin⁶⁸,Bruno Tullia C⁶,Cardello Carly⁶,Shan Feng⁶,Workman Creg⁶,Ray Prabir¹⁶,Ray Anuradha¹⁶,Lee Janet¹⁹,Sethi Rahil¹⁰,Schwarzmann William E¹⁰,Ladinsky Mark S¹¹,Bjorkman Pamela J¹¹,Vignali Dario A⁶,Duprex W Paul⁴⁵,Agha Mounzer E⁸,Mellors John W³,McCormick Kevin D³,Morris Alison¹,Haidar Ghady³

Affiliation:

1. Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

2. Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA

3. Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

4. Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

5. Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

6. Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

7. Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

8. Division of Hematology, Oncology, Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

9. Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

10. Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

11. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA

Abstract

Abstract A chimeric antigen receptor-modified T-cell therapy recipient developed severe coronavirus disease 2019, intractable RNAemia, and viral replication lasting >2 months. Premortem endotracheal aspirate contained >2 × 1010 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA copies/mL and infectious virus. Deep sequencing revealed multiple sequence variants consistent with intrahost virus evolution. SARS-CoV-2 humoral and cell-mediated immunity were minimal. Prolonged transmission from immunosuppressed patients is possible.

Funder

National Center for Advancing Translational Sciences

National Institutes of Health

U.S. Department of Veterans Affairs

University of Pittsburgh

University of Pittsburgh Medical Center

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciab072/36409747/ciab072.pdf

Reference20 articles.

1. COVID-19 outcomes in patients with hematologic disease;Malard;Bone Marrow Transplant,2020

2. Infections after anti-CD19 chimeric antigen receptor T-cell therapy for hematologic malignancies: timeline, prevention, and uncertainties;Haidar;Curr Opin Infect Dis,2020

3. Virological assessment of hospitalized patients with COVID-2019;Wolfel;Nature,2020

4. Profile of RT-PCR for SARS-CoV-2: a preliminary study from 56 COVID-19 patients;Xiao;Clin Infect Dis,2020

5. Highly sensitive quantification of plasma SARS-CoV-2 RNA sheds light on its potential clinical value [manuscript published online ahead of print 17 August 2020];Veyer;Clin Infect Dis,2020

Cited by 114 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. SARS-CoV-2 viral clearance and evolution varies by type and severity of immunodeficiency;Science Translational Medicine;2024-01-24

2. Current Technologies and Future Perspectives in Immunotherapy towards a Clinical Oncology Approach;Biomedicines;2024-01-18

3. COVID-19 in Children and Adolescents;Textbook of SARS-CoV-2 and COVID-19;2024

4. Overview of Nucleocapsid-Targeting Vaccines against COVID-19;Vaccines;2023-12-03

5. Chinese expert consensus on the management of patients with hematologic malignancies infected with SARS-CoV-2;Journal of Cancer Research and Therapeutics;2023-12