Emergence of a Severe Acute Respiratory Syndrome Coronavirus 2 Virus Variant With Novel Genomic Architecture in Hong Kong-Reference-Cited by-全球学者库

Emergence of a Severe Acute Respiratory Syndrome Coronavirus 2 Virus Variant With Novel Genomic Architecture in Hong Kong

Published:2021-03-02 Issue:9 Volume:73 Page:1696-1699
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Tse Herman¹,Lung David Christopher¹²,Wong Sally Cheuk-Ying¹,Ip Ka-Fai¹,Wu Tak-Chiu³,To Kelvin Kai-Wang⁴⁵,Kok Kin-Hang⁴⁵,Yuen Kwok-Yung⁴⁵,Choi Garnet Kwan-Yue¹

Affiliation:

1. Department of Pathology, Hong Kong Children’s Hospital, Hong Kong Special Administrative Region, China

2. Department of Pathology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China

3. Department of Medicine, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China

4. State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China

5. Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China

Abstract

Abstract Throughout the coronavirus disease 2019 (COVID-19) pandemic, divergent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages have emerged continuously, mostly through the genomic accumulation of substitutions. We report the discovery of a SARS-CoV-2 variant with a novel genomic architecture characterized by absent ORF7a, ORF7b, and ORF8, and a C-terminally modified ORF6 product resulting from partial 5′-untranslated region (UTR) duplication and transposition.

Funder

Health and Medical Research Fund

Food and Health Bureau

Hong Kong Special Administrative Region

Richard Yu and Carol Yu

Michael Seak-Kan Tong

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciab198/37655089/ciab198.pdf