Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO)
Author:
Schmitz Kathryn H1ORCID, Brown Justin C2ORCID, Irwin Melinda L3, Robien Kim4, Scott Jessica M5, Berger Nathan A6, Caan Bette7, Cercek Andrea8ORCID, Crane Tracy E9, Evans Scott R10, Ligibel Jennifer A11ORCID, Meyerhardt Jeffrey A12ORCID, Agurs-Collins Tanya13, Basen-Engquist Karen14, Bea Jennifer W15, Cai Sheng F16, Cartmel Brenda3, Chinchilli Vernon M17, Demark-Wahnefried Wendy18ORCID, Dieli-Conwright Christina M19, DiPietro Loretta20, Doerksen Shawna E1, Edelstein Sharon L21, Elena Joanne13, Evans William22, Ferrucci Leah M23, Foldi Julia1, Freylersythe Sarah9, Furberg Helena24, Jones Lee W5, Levine Ross16, Moskowitz Chaya S24, Owusu Cynthia25, Penedo Frank26, Rabin Borsika A27, Ratner Elena28, Rosenzweig Margaret29, Salz Talya24, Sanft Tara30, Schlumbrecht Matthew31, Spielmann Guillaume32, Thomson Cynthia A33, Tjaden Ashley H21, Weiser Martin R34ORCID, Yang Shengping35, Yu Anthony F5, Perna Frank M13, , Caan Bette, Anderson Sydney, Bahia Harmenjit, Castillo Adrienne, Feliciano Elizabeth, Johnson Kristina, Ross Michelle, Weltzein Erin, Brown Justin C, Albarado Baylea, Compton Stephanie, Green Tamara, Nash Ryan, Nauta Phillip, Welch Meredith, Yang Shengping, Meyerhardt Jeffrey A, Dieli-Conwright Christina M, Nguyen Danny, Pena Amalia Perez, Spielmann Guillaume, Kim Youyoung, Evans William J, Bea Jennifer W, Blew Robert M, Crane Tracy E, Bhatti Atif, Clavon Reanna, Erlandsen Stefan Spee, Freylersythe Sarah, Hollander Kenna, Lopez-Pentecost Melissa, Penedo Frank J, Rolle LaShae, Rossi Paola, Schlumbrecht Matthew, Wheeler Madalyn, Irwin Melinda L, Cao Anlan, Cartmel Brenda, Ferrucci Leah M, Gottlieb Linda, Harrigan Maura, Li Fang-Yong, McGowan Courtney, Puklin Leah, Ratner Elena, Sanft Tara, Zupa Michelle, Berger Nathan A, Cerne Stephen, Mills Carissa, Conochan Sandy, Hundal Jasmin, Owusu Cynthia, Ligibel Jennifer A, Campbell Nancy, DiGuglielmo Kaedryn, Kemp Wendy, Maples-Campbell Christopher, Nguyen Truong, Oppenheim Jay, Tanasijevic Anna, Thomson Cynthia, Yung Angela, Basen-Engquist Karen, Loomba Preena, Chinchilli Vernon M, Schmitz Kathryn H, Binder Jenna, Doerksen Shawna E, Foldi Julia, Garrett Sara, Scalise Raymond, Sobolewski Michele, White Lacey, Scott Jessica M, Cercek Andrea, Cai Sheng F, Cao Stephanie, Furberg Helena, Harrison Jenna, Jones Lee W, Lee Catherine, Levine Ross, Michalski Meghan, Moskowitz Chaya S, Novo Robert, Rabazzi Julia, Stoeckel Kurtis, Salz Talya, Weiser Martin R, Yu Anthony F, Demark-Wahnefried Wendy, Robien Kim, Evans Scott R, DiPietro Loretta, Duong Bao, Edelstein Sharon L, Helmchen Lorens, Le Daisy, McCleary Caitlin, Tjaden Ashley H, Wopat Heather, Rabin Borsika A, Perna Frank M, Agurs-Collins Tanya, Czajkowski Susan M, Elena Joanne, Nebeling Linda C, Norton Wynne E
Affiliation:
1. Hematology and Oncology, University of Pittsburgh, UPMC Hillman Cancer Center , Pittsburgh, PA, USA 2. Department of Cancer Energetics, Pennington Biomedical Research Center , Baton Rouge, LA, USA 3. Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University , New Haven, CT, USA 4. Department of Exercise and Nutrition Sciences and Department of Epidemiology, Milken Institute School of Public Health, George Washington University , Washington, DC, USA 5. Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine , New York, NY, USA 6. Department of Medicine, Division of Hematology and Oncology, Case Western Reserve University and Case Comprehensive Cancer Center , Cleveland, OH, USA 7. Division of Research, Kaiser Permanente of Northern California , Oakland, CA, USA 8. Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY, USA 9. Department of Medicine, Division of Medical Oncology, University of Miami, Sylvester Comprehensive Cancer Center , Miami, FL, USA 10. Biostatistics Center and Department of Biostatistics and Bioinformatics, Milken Institute School of Public Health, George Washington University , Washington, DC, USA 11. Division of Breast Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute , Boston, MA, USA 12. Gastrointestinal Cancer Center, Dana-Farber Cancer Institute , Boston, MA, USA 13. Division of Cancer Control and Population Sciences, National Cancer Institute , Bethesda, MD, USA 14. Department of Health Disparities Research, The University of Texas MD Anderson Cancer Center , Houston, TX, USA 15. Health Promotion Sciences, University of Arizona and University of Arizona Cancer Center , Tucson, AZ, USA 16. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center , New York, NY, USA 17. Department of Public Health Sciences, The Pennsylvania State University College of Medicine , Hershey, PA, USA 18. Department of Nutrition Sciences, University of Alabama at Birmingham , Birmingham, AL, USA 19. Division of Population Sciences, Dana-Farber Cancer Institute and Harvard Medical School , Boston, MA, USA 20. Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University , Washington, DC, USA 21. Biostatistics Center, Milken Institute School of Public Health, George Washington University , Washington, DC, USA 22. Department of Nutritional Sciences and Toxicology, University of California , Berkeley, Berkeley, CA, USA 23. Department of Chronic Disease Epidemiology, Yale School of Public Health and Yale Cancer Center , New Haven, CT, USA 24. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center , New York, NY, USA 25. Department of Medicine, Division of Hematology and Oncology, Case Western Reserve University , Cleveland, OH, USA 26. Departments of Psychology and Medicine and Sylvester Comprehensive Cancer Center, University of Miami , Miami, FL, USA 27. Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego , La Jolla, CA, USA 28. Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University , New Haven, CT, USA 29. School of Nursing, University of Pittsburgh , Pittsburgh, PA, USA 30. Section of Medical Oncology, Yale University , New Haven, CT, USA 31. Division of Gynecologic Oncology, Sylvester Comprehensive Cancer Center , Miami, FL, USA 32. School of Kinesiology, Louisiana State University , Baton Rouge, LA, USA 33. Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona , Tucson, AZ, USA 34. Department of Surgery, Memorial Sloan Kettering Cancer Center , New York, NY, USA 35. Department of Biostatistics, Pennington Biomedical Research Center , Baton Rouge, LA, USA
Abstract
Abstract
Chemotherapy treatment-related side effects are common and increase the risk of suboptimal outcomes. Exercise interventions during cancer treatment improve self-reported physical functioning, fatigue, anxiety, and depression, but it is unclear whether these interventions improve important clinical outcomes, such as chemotherapy relative dose intensity. The National Cancer Institute funded the Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO) Consortium to address this knowledge gap. This article describes the mechanisms hypothesized to underpin intervention effects on clinically relevant treatment outcomes, briefly outlines each project’s distinct research aims, summarizes the scope and organizational structure of ENICTO, and provides an overview of the integrated common data elements used to pursue research questions collectively. In addition, the article includes a description of consortium-wide activities and broader research community opportunities for collaborative research. Findings from the ENICTO Consortium have the potential to accelerate a paradigm shift in oncology care such that patients with cancer could receive exercise and nutrition programming as the standard of care in tandem with chemotherapy to improve relative dose intensity for a curative outcome.
Publisher
Oxford University Press (OUP)
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