Association of Genetic Ancestry With Terminal Duct Lobular Unit Involution Among Healthy Women

Author:

Sung Hyuna1ORCID,Koka Hela2,Marino Natascia34ORCID,Pfeiffer Ruth M2ORCID,Cora Renata2ORCID,Figueroa Jonine D5ORCID,Sherman Mark E6ORCID,Gierach Gretchen L2ORCID,Yang Xiaohong R2ORCID

Affiliation:

1. Surveillance and Health Equity Science, American Cancer Society , Atlanta, GA, USA

2. Division of Cancer Epidemiology and Genetics, National Cancer Institute , Bethesda, MD, USA

3. Susan G. Komen Tissue Bank at the IU Simon Comprehensive Cancer Center , Indianapolis, IN, USA

4. Department of Medicine, Indiana University School of Medicine , Indianapolis, IN, USA

5. Deanery of Molecular, Genetic and Population Health Sciences, Usher Institute, The University of Edinburgh, Scotland, UK

6. Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, USA

Abstract

Abstract Reduced age-related terminal duct lobular unit (TDLU) involution has been linked to increased breast cancer risk and triple-negative breast cancer. Associations of TDLU involution levels with race and ethnicity remain incompletely explored. Herein, we examined the association between genetic ancestry and TDLU involution in normal breast tissue donated by 2014 healthy women in the United States. Women of African ancestry were more likely than European women to have increased TDLU counts (odds ratio [OR]trend = 1.36, 95% confidence interval [CI] = 1.07 to 1.74), acini counts per TDLU (OR = 1.47, 95% CI = 1.06 to 2.03), and median TDLU span (ORtrend = 1.44, 95% CI = 1.08 to 1.91), indicating lower involution, whereas East Asian descendants were associated with decreased TDLU counts (ORtrend = 0.52, 95% CI = 0.35 to 0.78) after controlling for potential confounders. These associations are consistent with the racial variations in incidence rates of triple-negative breast cancer in the United States and suggest opportunities for future work examining whether TDLU involution may mediate the racial differences in subtype-specific breast cancer risk.

Funder

Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute

Intramural Research Department of the American Cancer Society

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

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