The unique risk factor profile of triple-negative breast cancer: a comprehensive meta-analysis

Author:

Kumar Nitya1ORCID,Ehsan Sarah2,Banerjee Shahana2,Fernandez Perez Claudia2,Lhuilier Isabelle2,Neuner Jillian2,Friebel-Klingner Tara3,Fayanju Oluwadamilola M2,Nair Bindhu1,Niinuma Sara Anjum1,Nampoothiri Shivangi4,McCarthy Anne Marie2

Affiliation:

1. Department of Medicine, Royal College of Surgeons in Ireland - Bahrain , Busaiteen, Bahrain

2. Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA, USA

3. Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University , Baltimore, MD, USA

4. Science Department, Christ University , Bangalore, KA, India

Abstract

Abstract Background Triple-negative breast cancer (TNBC) has a poor prognosis compared with other breast cancer subtypes. This systematic review and meta-analysis examines whether known risk factors for breast cancer are also associated with TNBC in adult women. Methods EMBASE, Medline, SCOPUS, and gray literature were queried with no limit on the date or language of publication. The exposures of interest included parity, breastfeeding, duration of breastfeeding, age at menarche, age at first live birth, oral contraceptive (OC) use, duration of OC use, use of menopausal hormone therapy (MHT), family history, body mass index (BMI), alcohol use, smoking, and breast density. The main outcome of interest was TNBC. Study quality was determined using the Newcastle-Ottawa scale for case control studies and cohort studies. We estimated weighted odds ratios from random effects models to study the exposure–outcome associations. Protocol was registered under the number: PROSPERO 2021 CRD42021254594. Results Thirty-three studies were included. Family history, longer duration of OC use, and higher breast density were significantly associated with increased risk for TNBC, whereas later age at menarche, later age at first birth, and breastfeeding were protective against TNBC. Parity, MHT, alcohol, smoking, and BMI were not significantly associated with TNBC overall, but higher parity was associated with higher risk among Black women. Conclusion Our findings highlight that TNBC has a distinct risk factor profile compared with overall breast cancer. This can be the foundational work in identification of actionable TNBC risk factors to improve prevention and early detection of these poor prognosis breast tumors.

Funder

RCSI-MUB Bahrain

American Cancer Society

National Institutes of Health

Breast Cancer Research Foundation

Gilead Sciences, Inc

Publisher

Oxford University Press (OUP)

Reference58 articles.

1. Comprehensive molecular portraits of human breast tumours;Cancer Genome Atlas Network;Nature,2012

2. Triple-negative breast cancer: distinguishing between basal and nonbasal subtypes;Rakha;Clin Cancer Res,2009

3. Relationship of established risk factors with breast cancer subtypes;McCarthy;Cancer Med,2021

4. Breast cancer intrinsic subtype classification, clinical use and future trends;Dai;Am J Cancer Res,2015

5. Impact of breast cancer subtypes and treatment on survival: an analysis spanning two decades;Haque;Cancer Epidemiol Biomarkers Prev,2012

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3