One stomach, two subtypes of carcinoma—the differences between distal and proximal gastric cancer

Author:

Zhang Yuan1ORCID,Zhang Peng-Shan1,Rong Ze-Yin1,Huang Chen1

Affiliation:

1. Department of Gastrointestinal Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, P. R. China

Abstract

Abstract Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract, posing a significant risk to human health. Over the past 10 years, the pathological characteristics and the prognosis of GC have been determined based on the locations of the tumors that were then classified into two types—proximal and distal GC. This review focuses on the differences in epidemiology, etiology, cell source, pathological characteristics, gene expression, molecular markers, manifestations, treatment, prognosis, and prevention between proximal and distal GC to provide guidance and a basis for clinical diagnosis and treatment.

Funder

National Natural Science Foundation of China

Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support

Shanghai Jiao Tong University Medical Cross Fund

Science and Technology Commission Project of Songjiang District

Three-year Action Plan for Clinical Skills and Clinical Innovation in Shanghai-level Hospitals

2021 Shanghai “Rising Stars of Medical Talent” Youth Development Program: Outstanding Youth Medical Talents

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology

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