Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA
Author:
Affiliation:
1. Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA, 2Institute of Clinical Chemistry and Pharmacology, University of Bonn, Bonn, Germany and 3Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Publisher
Oxford University Press (OUP)
Subject
Genetics
Link
http://academic.oup.com/nar/article-pdf/39/21/e142/25333739/gkr695.pdf
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4. Expression of therapeutic proteins after delivery of chemically modified mRNA in mice;Kormann;Nat. Biotechnol.,2011
5. Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability;Kariko;Mol. Ther.,2008
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