Early-Life Growth and Benign Breast Disease

Author:

Goldberg Mandy1,Cohn Barbara A2,Houghton Lauren C1,Flom Julie D1,Wei Ying3,Cirillo Piera2,Michels Karin B45,Terry Mary Beth167ORCID

Affiliation:

1. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York

2. Child Health and Development Studies, Public Health Institute, Berkeley, California

3. Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York

4. Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California

5. Institute for Prevention and Cancer Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg im Breisgau, Germany

6. Herbert Irving Comprehensive Cancer Center, Irving Medical Center, Columbia University, New York, New York

7. Imprints Center for Genetic and Environmental Lifecourse Studies, Mailman School of Public Health, Columbia University, New York, New York

Abstract

Abstract Using prospective data from the Early Determinants of Mammographic Density study (United States, 1959–2008, n = 1121), we examined the associations between maternal body size, birth size, and infant and early childhood growth during 3 time periods (0–4 months, 4–12 months, and 1–4 years) and benign breast disease (BBD) using multivariable logistic regression with generalized estimating equations. A total of 197 women (17.6%) reported receiving a diagnosis of BBD by a physician. Higher body mass index at age 7 years was inversely associated with BBD risk. Rapid weight gain from age 1 year to 4 years, defined as an increase of least 2 major percentiles (e.g., 5th, 10th, 25th, 50th, 75th, and 95th) relative to stable growth, defined as remaining within 2 percentiles, was also inversely associated with BBD (odds ratio (OR) = 0.51, 95% confidence interval (CI): 0.23, 1.15). In contrast, rapid weight gain in infancy was positively associated with BBD relative to stable growth (from 0 to 4 months, OR = 1.65, 95% CI: 1.04, 2.62; from 4 to 12 months, 1.85, 95% CI: 0.89, 3.85), independent of birth weight, which was not associated with BBD. Our results suggest that patterns of early-life weight gain are important to BBD risk. Thus, susceptibility to BBD, like susceptibility to breast cancer, might start in early life.

Funder

National Cancer Institute

National Institute of Child Health and Development

National Institute for Environmental Health Sciences

Publisher

Oxford University Press (OUP)

Subject

Epidemiology

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