The significance of long non-coding RNAs in the pathogenesis, diagnosis and treatment of inflammatory bowel disease-Reference-Cited by-全球学者库

The significance of long non-coding RNAs in the pathogenesis, diagnosis and treatment of inflammatory bowel disease

Published:2023-10-25 Issue:4 Volume:6 Page:
ISSN:2096-5303
Container-title:Precision Clinical Medicine
language:en
Short-container-title:

Author:

Jiang Fei¹²,Wu Min³⁴,Li Rongpeng¹^ORCID

Affiliation:

1. Jiangsu Province Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells, School of Life Sciences, Jiangsu Normal University , Xuzhou 221000 , China

2. Department of Laboratory Medicine, the Affiliated Hospital of Xuzhou Medical University , Xuzhou 221000 , China

3. Drug Discovery Section, Wenzhou Institute, University of Chinese Academy of Sciences , Wenzhou 325000 , China

4. Department of Neurology, Medical College of Wisconsin , Milwaukee, WI 53226 , USA

Abstract

Abstract Inflammatory bowel diseases (IBD) are a group of chronic relapsing gastrointestinal inflammatory diseases with significant global incidence. Although the pathomechanism of IBD has been extensively investigated, several aspects of its pathogenesis remain unclear. Long non-coding RNAs (lncRNAs) are transcripts with more than 200 nucleotides in length that have potential protein-coding functions. LncRNAs play important roles in biological processes such as epigenetic modification, transcriptional regulation and post-transcriptional regulation. In this review, we summarize recent advances in research on IBD-related lncRNAs from the perspective of the overall intestinal microenvironment, as well as their potential roles as immune regulators, diagnostic biomarkers and therapeutic targets or agents for IBD.

Funder

National Natural Science Foundation of China

Scientific Research Foundation of the Affiliated Hospital of Xuzhou Medical University

Priority Academic Program Development of Jiangsu Higher Education Institutions

Postgraduate Research & Practice Innovation Program of Jiangsu Province

Natural Science Foundation of Guizhou Provincial Scientific and Technology Department

Publisher

Oxford University Press (OUP)

Subject

General Medicine

Link

https://academic.oup.com/pcm/advance-article-pdf/doi/10.1093/pcmedi/pbad031/54257141/pbad031.pdf

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