Initiation and adherence to isoniazid preventive therapy in children under 5 years of age in Manhiça, Southern Mozambique-Reference-Cited by-同舟云学术

Initiation and adherence to isoniazid preventive therapy in children under 5 years of age in Manhiça, Southern Mozambique

Published:2022-12-05 Issue:1 Volume:69 Page:
ISSN:0142-6338
Container-title:Journal of Tropical Pediatrics
language:en
Short-container-title:

Author:

Montoya i de Manuel-Rimbau Agnès¹,Nguenha Dinis²³,Mambuque Edson²,Ehrlich Joanna¹,Munguambe Shilzia²,Saavedra Belén¹²,Matsena Teodimiro²,Chiconela Hélio²⁴,Casellas Aina¹,López-Varela Elisa¹²,Acacio Sozinho²,Garcia-Basteiro Alberto L¹²⁵^ORCID

Affiliation:

1. ISGlobal, Hospital Clínic, Universitat de Barcelona , Barcelona, Spain

2. Centro de Investigação em Saude de Manhiça , Manhiça, Maputo, Mozambique

3. Amsterdam Institute for Global Health and Development (AIGHD) , Amsterdam, The Netherlands

4. National Tuberculosis Control Programme , District of Manhiça, Mozambique

5. Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC) , Barcelona, Spain

Abstract

Abstract The WHO recommends preventive treatment for all pediatric contacts of a confirmed TB case, but coverage remains low in many high TB burden countries. We aimed to assess the coverage and adherence of the isoniazid preventive therapy (IPT) program among children under 5 years of age with household exposure to an adult pulmonary TB case in a rural district of Southern Mozambique. The estimated IPT coverage was 11.7%. A longer distance to the health center and lower age of the children hindered IPT initiation. Among patients who started IPT, 12/18 (69.9%) were adherent to the 6-month treatment.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Pediatrics, Perinatology and Child Health

Link

https://academic.oup.com/tropej/article-pdf/69/1/fmad009/48957220/fmad009.pdf

Reference21 articles.

1. Chapter 4: childhood contact screening and management;World Health Organization Stop TB Partnership Childhood TB Subgroup;Int J Tuberc Lung Dis,2007

2. Efficacy of isoniazid prophylactic therapy in prevention of tuberculosis in children: a meta-analysis;Ayieko;BMC Infect Dis,2014