Joint IARC/NCI International Cancer Seminar Series Report: expert consensus on future directions for ovarian carcinoma research

Author:

Virani Shama1ORCID,Baiocchi Glauco2,Bowtell David3,Cabasag Citadel J4,Cho Kathleen R5,Fortner Renée T6,Fujiwara Keiichi7,Kim Jae-Weon8,Köbel Martin9,Kurtz Jean-Emmanuel10,Levine Douglas A11,Menon Usha12ORCID,Norquist Barbara M13ORCID,Pharoah Paul D P14,Sood Anil K15,Tworoger Shelley T16ORCID,Wentzensen Nicolas17ORCID,Chanock Stephen J17ORCID,Brennan Paul1,Trabert Britton17ORCID

Affiliation:

1. International Agency for Research on Cancer (IARC/WHO), Genomic Epidemiology Branch, Lyon, France

2. Department of Gynecology Oncology, A.C. Camargo Cancer Center, São Paulo, SP, Brazil

3. Women’s Cancer Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia

4. Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France

5. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA

6. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

7. Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Tokyo, Japan

8. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea

9. Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada

10. Department of Medical and Surgical Oncology and Hematology, Strasbourg Cancer Institute (ICANS-Europe), Strasbourg, France

11. Gynecologic Oncology, Laura and Isaac Pearlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA

12. MRC CTU at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK

13. Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA

14. Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

15. Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

16. Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

17. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA

Abstract

Abstract Recently, ovarian cancer research has evolved considerably because of the emerging recognition that rather than a single disease, ovarian carcinomas comprise several different histotypes that vary by etiologic origin, risk factors, molecular profiles, therapeutic approaches and clinical outcome. Despite significant progress in our understanding of the etiologic heterogeneity of ovarian cancer, as well as important clinical advances, it remains the eighth most frequently diagnosed cancer in women worldwide and the most fatal gynecologic cancer. The International Agency for Research on Cancer and the United States National Cancer Institute jointly convened an expert panel on ovarian carcinoma to develop consensus research priorities based on evolving scientific discoveries. Expertise ranged from etiology, prevention, early detection, pathology, model systems, molecular characterization and treatment/clinical management. This report summarizes the current state of knowledge and highlights expert consensus on future directions to continue advancing etiologic, epidemiologic and prognostic research on ovarian carcinoma.

Funder

International Agency for Research on Cancer

Division of Cancer Epidemiology and Genetics, National Cancer Institute

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,General Medicine

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