Glucose-6-Phosphate Dehydrogenase Deficiency and Coronavirus Disease 2019

Author:

Israel Ariel12ORCID,Berkovitch Matitiahu23,Merzon Eugene14,Golan-Cohen Avivit12,Green Ilan12,Ruppin Eytan5,Vinker Shlomo12,Magen Eli16

Affiliation:

1. Leumit Research Institute and Department of Family Medicine, Leumit Health Services , Tel Aviv-Yafo , Israel

2. Sackler Faculty of Medicine, Tel-Aviv University , Tel Aviv-Yafo , Israel

3. Clinical Pharmacology and Toxicology Unit, Shamir Medical Center , Zerifin , Israel

4. Adelson School of Medicine, Ariel University , Ariel , Israel

5. Cancer Data Science Laboratory, National Cancer Institute , Bethesda, Maryland , USA

6. Medicine A Department, Assuta Ashdod University Hospital Faculty of Health Sciences, Ben-Gurion University , Beer-Sheba , Israel

Abstract

Abstract In this cohort study conducted in a national healthcare organization in Israel, we found that individuals with glucose-6-phosphate dehydrogenase deficiency had an increased risk of coronavirus disease 2019 (COVID-19) infection and severity, with higher rates of hospitalization and diagnosed long COVID.

Funder

Intramural Research Program

National Institutes of Health

National Cancer Institute

Center for Cancer Research

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Reference14 articles.

1. Glucose-6-phosphate dehydrogenase deficiency;Cappellini;Lancet,2008

2. Glucose-6-phosphate dehydrogenase deficiency (G6PD) as a risk factor of male neonatal sepsis;Rostami-Far;J Med Life,2016

3. Centrality of G6PD in COVID-19: the biochemical rationale and clinical implications;Buinitskaya;Front Med (Lausanne),2020

4. Association of glucose-6-phosphate dehydrogenase deficiency with outcomes in US veterans with COVID-19;Elsea;JAMA Netw Open,2023

5. Glucose-6-phosphate dehydrogenase deficiency and COVID-19 mortality, ICU admission, and length of hospitalization;Parnasa;Isr Med Assoc J,2023

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