Direct-Acting Antiviral Therapy for Treatment of Acute and Recent Hepatitis C Virus Infection: A Narrative Review

Author:

Martinello Marianne12ORCID,Naggie Susanna34,Rockstroh Juergen Kurt5,Matthews Gail V16

Affiliation:

1. Kirby Institute, University of New South Wales (UNSW Sydney) , Sydney , Australia

2. Prince of Wales Hospital , Sydney , Australia

3. Duke University Medical Center , Durham, North Carolina , USA

4. Duke Clinical Research Institute , Durham, North Carolina , USA

5. University Hospital Bonn , Bonn , Germany

6. St Vincent's Hospital , Sydney , Australia

Abstract

Abstract Following the discovery of hepatitis C virus (HCV) in 1989, 3 decades of basic, translational, and clinical research culminated in the development of direct-acting antiviral (DAA) therapy—curative oral treatment for HCV infection. The availability of DAA therapy revolutionized HCV clinical management, including acute (duration of infection <6 mo) and recent (duration of infection <12 mo) infection. Several DAA regimens, including the contemporary pan-genotypic combinations of sofosbuvir-velpatasvir and glecaprevir-pibrentasvir, have been shown to be safe and effective among people with acute and recent HCV infection, highlighting their potential in an HCV controlled human infection model. This article describes the natural history and management of acute and recent HCV infection in the era of DAA therapy and outlines a strategy for use of DAA therapies in the setting of an HCV controlled human infection model.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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