Energy Drinks Induce Acute Cardiovascular and Metabolic Changes Pointing to Potential Risks for Young Adults: A Randomized Controlled Trial

Author:

Basrai Maryam1,Schweinlin Anna1ORCID,Menzel Juliane2ORCID,Mielke Hans3ORCID,Weikert Cornelia2,Dusemund Birgit2,Putze Kersten4,Watzl Bernhard5ORCID,Lampen Alfonso2,Bischoff Stephan C1

Affiliation:

1. University of Hohenheim, Institute of Nutritional Medicine, Stuttgart, Germany

2. German Federal Institute for Risk Assessment, Department of Food Safety, Berlin, Germany

3. German Federal Institute for Risk Assessment, Department of Exposure, Berlin, Germany

4. Cardiac Center, Stuttgart, Germany

5. Max Rubner-Institut, Department of Physiology and Biochemistry of Nutrition, Karlsruhe, Germany

Abstract

ABSTRACTBackgroundCase reports suggest a link between energy drinks (EDs) and adverse events, including deaths.ObjectivesWe examined cardiovascular and metabolic effects of EDs and mixtures providing relevant ingredients of EDs compared to a similarly composed control product (CP) without these components.MethodsThis randomized, crossover trial comprised 38 adults (19 women, mean BMI 23 kg/m2, mean age 22 y). We examined effects of a single administration of a commercial ED, the CP, and the CP supplemented with major ED-ingredients at the same concentrations as in the ED. The study products were administered at 2 volumes, 750 or 1000 mL.ResultsBoth volumes of the study products were acceptably tolerated with no dose-dependent effects on blood pressure (BP, primary outcome), heart rate, heart rate corrected duration of QT-segment in electrocardiography (QTc interval), and glucose metabolism. After ED consumption, 11% of the participants reported symptoms, in contrast to 0–3% caused by other study products. After 1 h, administration of an ED caused an increase in systolic BP (116.9 ± 10.4 to 120.7 ± 10.7 mmHg, mean ± SD, P < 0.01) and a QTc prolongation (393.3 ± 20.6 to 400.8 ± 24.1 ms, P < 0.01). Also caffeine, but not taurine or glucuronolactone, caused an increase in BP, but no QTc prolongation. The BP effects were most pronounced after 1 h and returned to normal after a few hours. All study products caused a decrease in serum glucose and an increase in insulin concentrations after 1 h compared to baseline values, corresponding to an elevation in the HOMA-IR (ED + 4.0, other products + 1.0–2.8, all P < 0.001).ConclusionA single high-volume intake of ED caused adverse changes in BP, QTc, and insulin sensitivity in young, healthy individuals. These effects of EDs cannot be easily attributed to the single components caffeine, taurine, or glucuronolactone. This trial was registered at clinicaltrials.gov as NCT01421979.

Funder

German Federal Ministry of Food and Agriculture

Federal Office for Agriculture and Food

Publisher

Oxford University Press (OUP)

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

Reference46 articles.

1. Caffeinated energy drinks–a growing problem;Reissig;Drug Alcohol Depend,2009

2. Energy drinks: an assessment of their market size, consumer demographics, ingredient profile, functionality, and regulations in the United States;Heckman;Compr Rev Food Sci Food Saf,2010

3. A survey of energy drink consumption patterns among college students;Malinauskas;Nutr J,2007

4. Wired: energy drinks, jock identity, masculine norms, and risk taking;Miller;J Am Coll Health,2008

5. Event-related survey among high dose consumers of energy drinks. German Federal Institute for Risk Assessment (BfR);Lindtner;BfR Wissenschaft,2013

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