IC50-to-Ki: a web-based tool for converting IC50 to Ki values for inhibitors of enzyme activity and ligand binding
Author:
Publisher
Oxford University Press (OUP)
Subject
Genetics
Link
http://academic.oup.com/nar/article-pdf/37/suppl_2/W441/3905175/gkp253.pdf
Reference18 articles.
1. An Exact Correction to the “Cheng-Prusoff” Correction
2. Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
3. Calculation of inhibitor Ki and inhibitor type from the concentration of inhibitor for 50% inhibition for Michaelis-Menten enzymes
4. Estimation of competitive antagonist affinity from functional inhibition curves using the Gaddum, Schild and Cheng-Prusoíf equations
5. A linear equation that describes the steady-state kinetics of enzymes and subcellular particles interacting with tightly bound inhibitors
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