Affiliation:
1. MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
2. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China
Abstract
Abstract
Hand, foot, and mouth disease (HFMD), caused by enteroviruses, is a syndrome characterized by fever with vesicular eruptions mainly on the skin of the hands, feet, and oral cavity. HFMD primarily affects infants and young children. Although infection is usually self-limited, severe neurological complications in the central nervous system can present in some cases, which can lead to death. Widespread infection of HFMD across the Asia-Pacific region over the past two decades has made HFMD a major public health challenge, ranking first among the category C notifiable communicable diseases in China every year since 2008. This review summarizes our understanding of HFMD, focusing on the etiology and pathogenesis of the disease, as well as on progress toward antivirals and vaccines. The review also discusses the implications of these studies as they relate to the control and prevention of the disease.
Publisher
Oxford University Press (OUP)
Reference189 articles.
1. Virology, epidemiology, pathogenesis, and control of enterovirus 71;Solomon;Lancet Infect Dis,2010
2. Hand, foot, and mouth disease in China, 2008–12: an epidemiological study;Xing;Lancet Infect Dis,2014
3. Neurologic complications in children with enterovirus 71 infection;Huang;N Engl J Med,1999
4. Report of an outbreak of febrile illness with pharyngeal lesions and exanthem: Toronto, summer 1957; isolation of group A Coxsackie virus;Robinson;Can Med Assoc J,1958
5. ‘Hand, foot, and mouth disease’ associated with Coxsackie A5 virus;Flewett;J Clin Pathol,1963
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