Childhood Maltreatment, Educational Attainment, and IQ: Findings From a Multicentric Case-control Study of First-episode Psychosis (EU-GEI)-Reference-Cited by-同舟云学术

Childhood Maltreatment, Educational Attainment, and IQ: Findings From a Multicentric Case-control Study of First-episode Psychosis (EU-GEI)

Published:2022-02-09 Issue:3 Volume:48 Page:575-589
ISSN:0586-7614
Container-title:Schizophrenia Bulletin
language:en
Short-container-title:

Author:

Sideli Lucia¹²^ORCID,Schimmenti Adriano³,La Barbera Daniele⁴,La Cascia Caterina⁴,Ferraro Laura⁴,Aas Monica²⁵⁶,Alameda Luis²⁷,Velthorst Eva⁸⁹¹⁰,Fisher Helen L¹¹¹²,Caretti Vincenzo¹,Trotta Giulia²,Tripoli Giada²⁴,Quattrone Diego¹¹,Gayer-Anderson Charlotte¹¹¹³^ORCID,Seminerio Fabio⁴,Sartorio Crocettarachele⁴,Marrazzo Giovanna⁴,Lasalvia Antonio¹⁴^ORCID,Tosato Sarah¹⁴,Tarricone Ilaria¹⁵,Berardi Domenico¹⁶,D’Andrea Giuseppe¹⁶,Arango Celso¹⁷,Arrojo Manuel¹⁸,Bernardo Miguel¹⁹,Bobes Julio²⁰,Sanjuán Julio²¹,Santos Jose Luis²²,Menezes Paulo Rossi²³,Del-Ben Cristina Marta²⁴,Jongsma Hannah E²⁵²⁶,Jones Peter B²⁷²⁸,Kirkbride James B²⁵^ORCID,Llorca Pierre-Michel²⁸,Tortelli Andrea²⁹,Pignon Baptiste³⁰³¹³²^ORCID,de Haan Lieuwe³³,Selten Jean-Paul³⁴³⁵,Van Os Jim²³⁵³⁶,Rutten Bart P³⁵,Di Forti Marta¹¹,Morgan Craig¹²¹³,Murray Robin M²,Amoretti Silvia,Andreu-Bernabeu Álvaro,Baudin Grégoire,Beards Stephanie,Bonetto Chiara,Bonora Elena,Cabrera Bibiana,Carracedo Angel,Charpeaud Thomas,Costas Javier,Cristofalo Doriana,Cuadrado Pedro,Durán-Cutilla Manuel,Ferchiou Aziz,Fraguas David,Franke Nathalie,Frijda Flora,Llorente Cloe,Garcia-Portilla Paz,González Peñas Javier,Hubbard Kathryn,Jamain Stéphane,Jiménez-López Estela,Leboyer Marion,López Montoya Gonzalo,Lorente-Rovira Esther,M Díaz-Caneja Covadonga,Marcelino Loureiro Camila,Matteis Mario,Messchaart Elles,Moltó Ma Dolores,Mezquida Gisela,Moreno Carmen,Muratori Roberto,Juan Nacher,Parellada Mara,Pignon Baptiste,Rapado-Castro Marta,Ruggeri Mirella,Richard Jean-Romain,Rodríguez Solano José Juan,Sáiz Pilar A,Sánchez-Gutierrez Teresa,Sánchez Emilio,Schürhoff Franck,Seri Marco,Shuhama Rosana,Stilo Simona A,Termorshuizen Fabian,Tronche Anne-Marie,van Dam Daniella,van der Ven Elsje,

Affiliation:

1. Department of Human Science, LUMSA University, Rome, Italy

2. Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, England

3. Faculty of Human and Social Sciences, UKE - Kore University of Enna, Enna, Italy

4. Department of Biomedicine, Neuroscience, and Advanced Diagnostic, University of Palermo, Palermo, Italy

5. NORMENT, Centre for Research On Mental Disorders, Oslo University Hospital and University of Oslo, Norway

6. Department of Mental Health Research and Development, Division of Mental Health and Addiction, Vestre Viken Hospital Trust, Norway

7. Departamento de Psiquiatria, Centro Investigacion Biomedica en Red de Salud Mental (CIBERSAM), Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocio, Universidad de Sevilla, Sevilla, Spain

8. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA

9. Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, USA

10. Early Psychosis Section, Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

11. King’s College London, Social, Genetic, & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, England

12. ESRC Centre for Society and Mental Health, King’s College London, London, UK

13. Department of Health Services and Population Research, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, England

14. Section of Psychiatry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy

15. Department of Medical and Surgical Sciences, Alma Mater Studiorum - Bologna University, Italy

16. Department of Biomedical and NeuroMotor Sciences, Psychiatry Unit, Alma Mater Studiorum Università di Bologna, Bologna, Italy

17. Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, ISGM, CIBERSAM, Madrid, Spain

18. Department of Psychiatry, Psychiatric Genetic Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago, Spain

19. Barcelona Clinic Schizophrenia Unit, Hospital Clinic, Department of Medicine, Neuroscience Institute, University of Barcelona, Institut d’Investigacions Biomèdiques, August Pi I Sunyer, Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain

20. Department of Medicine, Psychiatry Area, Universidad de Oviedo, ISPA, INEUROPA, CIBERSAM, Oviedo, Spain

21. Department of Psychiatry, Centro de Investigación Biomédica en Red de Salud Mental, School of Medicine, Universidad de Valencia, Valencia, Spain

22. Department of Psychiatry, Hospital “Virgen de la Luz”, Cuenca, Spain

23. Department of Preventive Medicine, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

24. Division of Psychiatry, Department of Neuroscience and Behaviour, Ribeirão Preto Medical School, Universidade de São Paulo, São Paulo, Brazil

25. PsyLife Group, Division of Psychiatry, University College London, London, England

26. Department of Psychiatry, University of Cambridge, Cambridge, England

27. CAMEO Early Intervention Service, Cambridgeshire and Peterborough National Health Service Foundation Trust, Cambridge, England

28. EA 7280 Npsydo, Université Clermont Auvergne, Clermont-Ferrand, France

29. Establissement Public de Santé, Maison Blanche, Paris, France

30. AP-HP, Groupe Hospitalier “Mondor,” Pôle de Psychiatrie, Créteil, France

31. Institut National de la Santé et de la Recherche Médicale, U955, Créteil, France

32. Fondation Fondamental, Créteil, France

33. Early Psychosis Section, Department of Psychiatry, Amsterdam UMC, Amsterdam, The Netherlands

34. Institute for Mental Health, GGZ Rivierduinen, Leiden, The Netherlands

35. Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands

36. Department Psychiatry, Utrecht University Medical Centre, Utrecht, The Netherlands

Abstract

Abstract Background and hypothesis Evidence suggests that childhood maltreatment (ie, childhood abuse and childhood neglect) affects educational attainment and cognition. However, the association between childhood maltreatment and Intelligence Quotient (IQ) seems stronger among controls compared to people with psychosis. We hypothesised that: the association between childhood maltreatment and poor cognition would be stronger among community controls than among people with first-episode of psychosis (FEP); compared to abuse, neglect would show stronger associations with educational attainment and cognition; the association between childhood maltreatment and IQ would be partially accounted for by other risk factors; and the association between childhood maltreatment, educational attainment, and IQ would be stronger among patients with affective psychoses compared to those with nonaffective psychoses. Study Design 829 patients with FEP and 1283 community controls from 16 EU-GEI sites were assessed for child maltreatment, education attainment, and IQ. Study Results In both the FEP and control group, childhood maltreatment was associated with lower educational attainment. The association between childhood maltreatment and lower IQ was robust to adjustment for confounders only among controls. Whereas childhood neglect was consistently associated with lower attainment and IQ in both groups, childhood abuse was associated with IQ only in controls. Among both patients with affective and nonaffective psychoses, negative associations between childhood maltreatment and educational attainment were observed, but the crude association with IQ was only evident in affective psychoses. Conclusions Our findings underscore the role of childhood maltreatment in shaping academic outcomes and cognition of people with FEP as well as controls.

Funder

European Community’s Seventh Framework Programme

São Paulo Research Foundation

Economic and Social Research Council

Instituto de Salud Carlos III

Fundación Familia Alonso

Fundación Alicia Koplowitz

Publisher

Oxford University Press (OUP)

Subject

Psychiatry and Mental health

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