Human papillomavirus-related oropharyngeal carcinoma

Author:

Saito Yuki1ORCID,Homma Akihiro23,Kiyota Naomi45,Tahara Makoto6,Hanai Nobuhiro7,Asakage Takahiro8,Matsuura Kazuto9,Ota Ichiro10ORCID,Yokota Tomoya11ORCID,Sano Daisuke1213,Kodaira Takeshi14,Motegi Atsushi15,Yasuda Koichi1617,Takahashi Shunji18ORCID,Tanaka Kaoru19,Onoe Takuma20,Okano Susumu6ORCID,Imamura Yoshinori45ORCID,Ariizumi Yosuke8,Hayashi Ryuichi9

Affiliation:

1. Department of Otolaryngology and Head and Neck Surgery, University of Tokyo , Tokyo, Japan

2. Department of Otolaryngology-Head and Neck Surgery , Faculty of Medicine and Graduate School of Medicine, , Sapporo, Japan

3. Hokkaido University , Faculty of Medicine and Graduate School of Medicine, , Sapporo, Japan

4. Department of Medical Oncology and Hematology , Cancer Center, , Kobe, Japan

5. Kobe University Hospital , Cancer Center, , Kobe, Japan

6. Department of Head and Neck Medical Oncology, National Cancer Center Hospital East , Kashiwa, Japan

7. Department of Head and Neck Surgery, Aichi Cancer Center Hospital , Nagoya, Japan

8. Department of Head and Neck Surgery, Tokyo Medical and Dental University , Tokyo, Japan

9. Department of Head and Neck Surgery, National Cancer Center Hospital East , Kashiwa, Japan

10. Department of Otolaryngology-Head and Neck Surgery, Nara Medical University , Nara, Japan

11. Divisions of Gastrointestinal Oncology, Shizuoka Cancer Center , Kashiwa, Japan

12. Department of Otorhinolaryngology , Head and Neck Surgery, , Yokohama, Japan

13. Yokohama City University, School of Medicine , Head and Neck Surgery, , Yokohama, Japan

14. Department of Radiation Oncology, Aichi Cancer Center Hospital , Nagoya, Japan

15. Department of Radiation Oncology, National Cancer Center Hospital East , Kashiwa, Japan

16. Department of Radiation Oncology , Faculty of Medicine and Graduate School of Medicine, , Japan

17. Hokkaido University , Faculty of Medicine and Graduate School of Medicine, , Japan

18. Department of Medical Oncology, Cancer Institute Hospital , Tokyo, Japan

19. Department of Medical Oncology, Kindai University Faculty of Medicine , Higashi-Osaka, Japan

20. Division of Medical Oncology, Hyogo Cancer Center , Hyogo, Japan

Abstract

Abstract It was not until around 2000 that human papillomavirus-related oropharyngeal carcinoma was recognized as carcinoma with clinical presentations different from nonrelated head and neck carcinoma. Twenty years after and with the revision of the tumor–node–metastasis classification in 2017, various clinical trials focused on human papillomavirus-related oropharyngeal carcinoma to improve the prognosis and quality of life of patients with this disease. However, the incidence of human papillomavirus-related cancers is increasing, which is expected to be particularly prominent in Japan, where human papillomavirus vaccination is not widely available. In this review, we describe the current status of clinical trials (mainly focused on initial surgery and radiation dose reduction) for, primary and secondary prevention of, and the present status of human papillomavirus-related oropharyngeal carcinoma in Japan.

Funder

National Cancer Center Research and Development

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology,General Medicine

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